3B). R526 within the loop among ?J and ?I anchors the C-terminal part of the activation loop by forming a salt bridge with E458 at the base of ?EF. Q459 stabilizes the HRD motif by a hydrogen bond to the principle chain carbonyl of R413. The idea in the activation phase is stabilized by a hydrogen bond amongst Y454 and E480 from ?F. during the FTF

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